Color coding for tablet coating

Color coding for tablet coating
 

1. Pink color , Light pink color :      Erythrosine lake pink + Titanium Dioxide

2. Green Color, Lignt green color: 
     a. Lake erythrosine  green + Titanium Dioxide
     b. Quinoline yellow + Lake Brilient Blue + Titanium Dioxide

3. Yellow color , Light Yellow color:
     a. Lake yellow color + Titanium Dioxide
     b. Quinoline yellow  +  Titanium Dioxide

4. Orange color:
     Quinoline yellow +  Erythrosine lake pink + Titanium Dioxide

5. Brown color:
     Quinoline yellow + Red oxide + Titanium Dioxide

6. Violet: 
     Erythrosine lake pink + Indizotin lake + Titanium Dioxide

Emergency Contraceptives Pill

Emergency Contraception:

Emergency contraception is known as a emergency postcoital contraception. Emergency contraception taken after sex, may prevent pregnancy. It also known as morning after pill . 

Emergency contraceptive pills:
Emergency contraceptive pills are prefer to as emergency contraceptives or the morning after pill. This drugs are prevent to ovulation or fertilization and possible post-fertilization implantation of a blastocyst. Emergency contraceptive pills are act after implantation when the fertilized egg is implanted in the womb. It different from medical abortion methods.

Dose:
1. Levonorgestrel  0.75mg per tablet.
    Emergency contraceptive 1 tablet with in 72 hr after intercourse and 2nd tablet 12 hr after the 1st dose.


Side Effect:
-  Upset stomach
-  Vomiting 
-  Stomach pain
-  Fatigue
-  Dizziness and Headache
-  Irregular bleeding
-  Breast tenderness

Mottling in Tablet

Mottling

Definition: ‘Mottling’ is that the term accustomed describe associate unequal distribution of color on a pill, with lightweight or dark spots standing go into associate otherwise uniform surface.

Reason: One reason for marking is also a colored drug, whose color differs from the color of excipients used for granulation of a pill.

The causes and remedies of marking.

  
CAUSES
   
1. A colored drug used in conjunction with colorless or white-colored Excipient.
2. A dye migrates to the surface of granulation whereas drying.
3. Improperly mixed dye, particularly throughout ‘Direct Compression’.
4. Improper mixture of a colored binder resolution.
   

REMEDIES
1. Use applicable colorants.Change the solvent system,
2. Change the binder, Reduce drying temperature and Use a smaller particle size.
3. Mix properly and cut back size if it's of a bigger size to forestall segregation.4. Incorporate dry color additive throughout powder mixing step, then add fine pulverized adhesives like tree and gum and blend well and at last add granulating liquid.

Binding of Tablet

Binding

Definition: ‘Binding’ within the die, is that the term used once the tablets adhere, seize or tear within the die. a movie is created within the die and ejection of pill is hindered. With excessive binding, the pill sides area unit cracked and it should crumble apart.

Reason: Binding is sometimes owing to excessive quantity of wet in granules, lack of lubrication and/or use of worn dies.

The causes and remedies of binding associated with ‘Formulation’ (granulation).

   
CAUSES:
1.  Too damp granules and extrudes around lower punch.
2.  Insufficient or improper lubricating substance.\
3.  Too coarse granules.   
4.  Too onerous granules for the lubricating substance to be effective.
5.  Granular material terribly abrasive and cutting into dies.
6.  Granular material too heat, sticks to the die.
   
REMEDIES:
1.  Dry the granules properly.
2.  Increase the quantity of lubricating substance or use a more practical lubricating substance.
3.  Reduce granular size, add a lot of fines, and increase the amount of lubricating substance.
4.  Modify granulation. cut back granular size.
5.  If coarse granules, cut back its size. Use wear-resistant dies.Reduce temperature.
6.  Increase clearance if it's extruding.


The causes and remedies of binding associated with ‘Machine’ (dies, punches and pill press).

 CAUSES:
    
1. Poorly finished dies.
2. Rough dies owing to abrasion, corrosion.   
3.  Undersized dies. insufficient  clearance.
4. Too much pressure within the pill press.
   
REMEDIES:
1.  Polish the dies properly.
2.  Investigate alternative steels or alternative materials or modify granulation.
3.  Rework to correct size. Increase clearance.
4.  Reduce pressure or Modify granulation.