Sticking in Tablet

Sticking: 

 

Sticking refers to pill material adhering to the die wall. once jutting happens extra force is needed to beat the friction between the tablets and die wall throughout ejection.



Causes of  Sticking:

1  Granules properly not dried
2  Improper or very little lubrication.
3 an excessive amount of binder.
4  Too weak or soft  granules.
5  Granules materials is absorbent .
6 once materials is oily

Remedies:

1   Granules properly dried and Determin wetness  limits.
2 modification or increase material.
3 modification form of binder and cut back the quantity of binder.
4 humidness is controll throughout compression and Modify granulation.
5  Add associate degree absorbent. Modify admixture method.
6  Optimize the granulation technique.

Chipping in Tablet

Chipping:

Divided into two same half or divided from the center purpose of the tablets.
Or

Chipping is outlined because the breaking of pill edges, whereas the pill leaves the press or throughout subtenant handling and coating operation.
Reason: Incorrect machine settings, specially mis-set ejection commence.


The causes and remedies of splintering associated with ‘Formulation’ (granulation).

CAUSES:
  

1.  Sticking on punch faces
2.  Too dry granules.
3.  Too much binding causes splintering in spite of appearance.
    
REMEDIES:

1.  Dry the granules properly or increase lubrication.
2.  Moisten the granules to plasticize. Add absorbent  substances.Optimize binding, or use dry binders.
3.  The causes and remedies of splintering associated with ‘Machine’ (dies, punches and pill press).


The causes and remedies of splintering associated with ‘Machine’ (dies, punches and pill press).
   
CAUSES
   
1.  Groove of die worn at compression purpose.
2.  Barreled die (center of the die wider than ends) 
3.  Edge of punch face turned inside/inward.
4.  Concavity too deep to compress properly.
   
REMEDIES:

1.  Polish to open finish, reverse or replace the die.
2.  Polish the die to form it cylindrical.
3.  Polish the punch edges .
4.  Reduce concavity of punch faces. Use flat punches..

Absorbent

 
Absorbent:




 


An agent capable of holding different molecules onto its surface by physical or chemical suggests that.

Example:
- carbon
- high-powered polysaccharide

Surfactant

Surfactant:

An agent used to reduce interfacial tension . May be used as agent , detergents or emulsifying agents.

Examlep:

- Sodium lauryl sulfate
- polysorbate 80

Glidants

Glidants:

 Excipient that added to tablet formulations to promote the flow of granulation by reducing friction between particles (use to improve flow property).

Example:

-  Silica 

-  Magnesium 

-  Stearate 

-  Calcium stearate 

-  Starch / Talc

Coloring Agents

Coloring Agents:

An agent that use for increasing physical appearance & compatibility & the pharmaceutical dosage form.

Color from plant:  

-  FD and C red no. 3 

-  Caramel

-  Chlorophyll (Green) 

-  B-carotene (Yellow / Orange)

Color is normally added by

-         Dissolving the dye in the binding solution

-         Spraying the granules with a special solution of the dye

-         Distributing the dye with the dry mix and then employing wet granulation.

Flavoring Agents

 Flavoring Agents: 

 Pharmaceutical necessity added to oral dosage form to musk the test unpleasant flavor of the drug.

Example:

-  Banana flavor

-  Strawberry flavor

-  Mango flavor etc.

-  peppermint oil

-  Vanilla