Mottling
Definition: ‘Mottling’ is that the term accustomed describe associate unequal distribution of color on a pill, with lightweight or dark spots standing go into associate otherwise uniform surface.
Reason: One reason for marking is also a colored drug, whose color differs from the color of excipients used for granulation of a pill.
The causes and remedies of marking.
CAUSES
1. A colored drug used in conjunction with colorless or white-colored Excipient.
2. A dye migrates to the surface of granulation whereas drying.
3. Improperly mixed dye, particularly throughout ‘Direct Compression’.
4. Improper mixture of a colored binder resolution.
REMEDIES
1. Use applicable colorants.Change the solvent system,
2. Change the binder, Reduce drying temperature and Use a smaller particle size.
3. Mix properly and cut back size if it's of a bigger size to forestall segregation.4. Incorporate dry color additive throughout powder mixing step, then add fine pulverized adhesives like tree and gum and blend well and at last add granulating liquid.
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