Noyes-Whitney
Equation:
Noyes & Whitney described the quantitative analysis of
the amount of drug dissolved from a solid particle as a function of time.
Derivation from Fick’s law of diffusion:
Equation:
Dc /S
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h
Where,
c = amount of drug dissolved (mg) in time t(s).
Dc = diffusion coefficient of the drug (cm2s-1).
S = surface area of drug (cm2)
h = thickness of the diffusion layer liquid film (cm).
Cs = Saturation solubility of the drug (mg.cm-3).
C = concentration of drug in bulk solution (mg.cm-3).
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