Process of Granulation for Tablets

Granulation:  It is a process if making particulate mass from fine powdered of drug or excipients.

Purpose of granulation –

-        It helps to prevent powder segregation.

-        It use for improve the flow properties of the mixtures

-        It use for improve the compaction properties of the mixtures

Granules - Primary powder particles are made to adhere to from larger, multi particle entities is so called granules. Size range for tablet or capsule is 0.2mm-0.4mm.

There is two types of granulation process are available:

1.      Dry manufacturing method:

1. Dry method of direct compression.

 Process – Raw material weighing> Screening>  Mixing (some time)> Compression > Coating> Packaging.
  

1. Dry granulation

Process – Raw material weighing> Screening> Mixing> Compression(Slugging)> Milling>Sieving> Final Mixing> Compression> Coating> Packaging.

2.    Wet granulation: Use Planetary mixer for wet massing. High speed mixture / Granulator.

   

Process – Raw material weighing> Screening> Mixing>Wet mass> Milling> Drying> Milling> Final Mixing> Compression> Coating> Packaging.

                

          Fig. Name of the machine of different steps of solid / liquid dosage forms

Mesh size – mesh size 20 is called the screen contain 20 pore per square inches (PSI)