Lamination in Tablet

Lamination:

Lamination is that the separation of a pill into 2 or additional distinct horizontal layers.

Reason: These issues occur owing to meagerly binder, improper granulation, layering of granules. Pressure personality disorder, defense of air into the entire of the pill, war punch, lack of enough fine powders.


The Causes and Remedies of Lamination associated with ‘Formulation’ (granulation).
  
CAUSES:
   
1.   Oily or waxy materials in granules.   
2.  Too much of hydrophobic material e.g.: Magnesium-stearate.
   
REMEDIES:

1. Modify combining method. Add adsorbent or absorbent.
2.  Use a less quantity of material or amendment the sort of material.

 
The causes and remedies of lamination associated with ‘Machine’ (dies, punches and pill press).

CAUSES:
   
1.   Rapid relaxation of the peripheral regions of the pill, on ejection of the die.
2.   Rapid decompression
   
REMEDIES:

1. Use tapered dies, i.e. higher a part of the die bore has Associate in Nursing outward taper of 3° to 5°.
2.  Use pre-compression step. scale back turret speed and scale back the ultimate compression pressure.