Picking in tablet

 Picking:  

Definition: ‘Picking’ is that the term used once atiny low quantity of fabric from a pill is protrusive to and being removed aloof from the tablet-surface by a punch face.

The problem is additional current on the higher punch faces than on the lower ones. the matter worsens, if tablets ar repeatedly factory-made during this station of tooling owing to the additional and additional material obtaining more to the already stuck material on the punch face.

Reason: choosing is of explicit concern once punch tips have engraving or embossing letters, moreover because the granular material is badly dried.


The causes and remedies of choosing associated with ‘Formulation’ (granulation).


CAUSES
   
1    Excessive wet in granules.   
2   Too little or improper lubrication.  
3  Low freezing point substances, could soften from the warmth of compression and cause choosing.   
4  Low freezing point drug in high concentration.
5  Too heat granules once pressing.  
6  Too much quantity of binder.
   

REMEDIES:

1.  Dry properly the granules, confirm optimum limit.
2.  Increase lubrication; use mixture silicon dioxide as a ‘polishing agent’, so material doesn't hold tight punch faces.
3.  Add high melting-point materials. Use high meting purpose lubricants.
4.  Refrigerate granules and also the entire pill press.
5.  Compress at temperature. Cool sufficiently before compression.
6.  Reduce the number of binder, amendment the kind or use dry binders.


The causes and remedies of choosing associated with ‘Machine’ (dies, punches and pill press).
   
CAUSES:   
1.  Rough or scraped punch faces. 
2.  Embossing or engraving letters on punch faces like B, A, O, R, P, Q, G.   
3.  Bevels or dividing lines too deep.
4.  Pressure applied isn't enough; too soft tablets.
   

REMEDIES:

1.  Polish faces to high luster.
2. Design inscription as massive as attainable. Plate the punch faces with metal to provide a sleek and non-adherent face.
3.  Reduce depths and sharpness.
4.  Increase pressure to optimum.