Disintegrating Agent

Disintegrators:

Disintegrators are substance which is added to tablet formulations, when needed to induce the tablet to disintegrate after administration.

For example:

- Dried corn 

- Potato starch 

- Starch 

- Cellulose 

- Sodium starch glycolate 

- Cross linked polyvinyl pyrrolidone 

- Sodium CMC

Dried corn or potato starch and cellulose derivatives are the most popular disintegrating agent.

         Nmae of Materials                                   Using Concentration

Carboxymethylcellulose calcium	1 – 15 %
Carboxymethylcellulose sodium	1 – 15 %
Croscarmellose sodium	D.C = 2 %
	W.G = 3 %
Crospovidone	2 – 5 %
Pregelatinized starch	5 – 10 %
Microcrystalline cellulose	5 –15 %
Maize starch	3 – 15 %
Sodium starch glycolate	2 – 8 %