Tuesday, June 25, 2013

Chipping in Tablet

Chipping:


Divided into two same half or divided from the center purpose of the tablets.
Or

Chipping is outlined because the breaking of pill edges, whereas the pill leaves the press or throughout subtenant handling and coating operation.
Reason: Incorrect machine settings, specially mis-set ejection commence.


The causes and remedies of splintering associated with ‘Formulation’ (granulation).

CAUSES:
  

1.  Sticking on punch faces

2.  Too dry granules.
3.  Too much binding causes splintering in spite of appearance.
    

REMEDIES:

1.  Dry the granules properly or increase lubrication.
2.  Moisten the granules to plasticize. Add absorbent  substances.Optimize binding, or use dry binders.
3.  The causes and remedies of splintering associated with ‘Machine’ (dies, punches and pill press).


The causes and remedies of splintering associated with ‘Machine’ (dies, punches and pill press).

   
CAUSES
   
1.  Groove of die worn at compression purpose.

2.  Barreled die (center of the die wider than ends) 
3.  Edge of punch face turned inside/inward.
4.  Concavity too deep to compress properly.
   

REMEDIES:

1.  Polish to open finish, reverse or replace the die.
2.  Polish the die to form it cylindrical.
3.  Polish the punch edges .
4.  Reduce concavity of punch faces. Use flat punches..

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