Friday, May 24, 2013

Tablet in Pharmaceuticals



Tablet : Tablet is solid dosage forms containing medicinal substances with or without suitable diluents.
Type of tablets :
a.      Oral tablets for ingestion
-        Compressed tablets
-        Multiple compressed tablets
Layered tablets
Compression coated tablets
-        Repeat action tablets
-        Delayed action tablets and enteric coated tablets
-       chocolate  coated and Sugar coated tablets
-        Film coated tablets
-        Chewable tablets
b.      Tablets used in the oral cavity
-        Buccal tablets
-        Sublingual tablets
-        Troches and lozenges
-        Dental cones
c.      Tablets administered by other routes
-        Implantation tablets
-        Vaginal tablets
d.      Tablets used to prepare solution
-        Effervescent tablets
-        Dispensing tablets (DT)
-        Hypodermic tablets (HT)
-        Tablets triturates (TT)

Multiple compressed tablets – Multiple compressed tablets are prepared by subjecting the fill materials to more than a single compression.
Route – Oral cavity, sub-lingual, Buccal, dental cones.
Effervescent tablets – Oral solid dosage form that is added to water before ingesting. The tablets contain sodium bicarbonate and an organic acids (citric acid / tartaric acid), evolved Carbon-dioxide gas.
Dispersible tablet – Uncoated tablet that produce a uniform dispersion, which not evolved any gas


About Tablet Manufacturing – 
-       Tablets Hardness should be generally 4 kg 
-       Weight may be variation – ±5% 
-       Disintegration – The specified time generally falls between 15 to 20 minutes.
-     Compressed tablet – In addition to the medicinal agent(s) compressed tablet contain a number of pharmaceutical excipients including filler or diluent. Binders, disintegration, ant adherents, lubricants, glidants, coloring and flavoring agents.

Double impression – This involves only punches that have a monogram or other engraving on them. Imprinting is mainly dome by lower punch. In some machines the lower punch is froe to drop and travel uncontrolled in a short distance.

*During this force movement, the punch rotates. At now the punch might create a brand new, though lighter impression on bottom of the pill, leading to double imprint.

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