In Process Control for Solid Dosage Form

IPC Checks for solid dosage form :

1. Dispensing:

-        Calibration of balance

-        Cleaning of balance

-        Proper checking of weight

-        Accuracy of weight

-        Perform the recoding of weight 

2. Granulation : 

-        Mixing time and speed, Temperature (Thermometer)

-        Properly milling, Particle size reduction, time

-        Drying temperature (inlet & outlet), Time & speed, Pressure & vacuum, Moisture content of in-process material / products

3. Blending : Homogeneity of the content   
4.  Compression:

-        Machine speed

-        Compression pressure

-        Hardness of tablets (Hardness tester)

-        Appearance of tablets

-        Thickness of tablets

-        Friability of tablets (Friabilator)

-        Weight variation (Balance)

-        Dissolution time

-        Disintegration time

-        Moisture content of tablet (Hygrometer)

5. Coating :

-        Temperature (inlet & outlet)

-        Speed (Revolution) and time

-        Uniformity  of color (Mottling test)

-        Appearance

-        Viscosity of coating solution